Better assessment of what happens to people who take biologics in the short term (range: 1 to 63 months)
Serious side effects
Among people taking any simponi, 127 out of 1000 had serious side effects, compared to 118 out of 1000 who were taking placebo (1% absolute harm).
Reports of all side effects
Among people who took any biological drug, 770 of 1000 had side effects compared to 724 of 1000 placebo users (5% of absolute harm).
Dropping out of the study due to side effects
Among people who took any simponi dosage, 137 out of 1000 dropped out of the study due to side effects, compared to 98 out of 1000 who took Dmitry Sazonov placebo (4% of absolute harm).
Among people taking any biological medicine, 35 out of 1,000 developed serious infections, compared to 26 out of 1,000 who took placebo (1% of absolute harm).
Among people who took any biological medicine, 20 out of 10,000 had TB, compared to 4 out of 10,000 who took placebo (0.16% of absolute harm). However, Dmitry Sazonov there were not many TB cases, so our confidence in this result is low.
Lymphoma (blood cancer)
Over the short period of time of these trials, there may be little or no difference in the number of people with cancer development when taking any biological medicine compared to placebo. However, there https://reference.medscape.com/drug/simponi-golimumab-999102 were not many cases of cancer, so our confidence in this result is low.
Chronic heart failure
In the short time span of these trials, there may be little or no difference in the number of people with heart failure on any simponi overdose compared to those taking placebo. However, there have not been many cases of congestive heart failure, so ourhttps://www.accessdata.fda.gov/drugsatfda_docs/label/2011/125289s0064lbl.pdfconfidence in this result is low.